Study of Cadmium and Chlorpyrifos Induced Changes in Protein and Lipid Profile in Rats

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Authors

  • Y. Ravikumar
     Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana ,IN
  • D. Madhuri
     Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana ,IN
  • M. Lakshman
     Department of Veterinary Pathology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana ,IN
  • A. Gopala Reddy
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Jagtial District, Telangana – 505326, Telangana ,IN
  • B. Kalakumar
     Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telengana ,IN

DOI:

https://doi.org/10.18311/ti/2020/v27i1&2/25279

Keywords:

Cadmium, Chlorpyrifos, Lipid Profile, Protein Profile, Wistar Rats

Abstract

The present work was aimed to know the changes in protein and lipid profile induced cadmium and chlorpyrifos Wistar rats. Work was carried out for 28 days in rats. 1: Control. 2: CdCl2 @ 22.5 mg/kg b.wt/oral. 3: CPF @ 25 mg/kg b.wt/per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/kg b.wt/per oral. Results revealed a significant (P<0.05) decrease in the concentration of total protein and albumin in Groups 2, 3 and 4 and also a significant (P<0.05) increase in total cholesterol, triglycerides and phospholipids in Groups 2, 3 and 4 on 15th and 29th day of the experiment. The adverse changes in protein and lipid profile in combined Group were severe than individual Groups due to synergistic action of the combined pollutants.

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Published

2020-10-01

How to Cite

Ravikumar, Y., Madhuri, D., Lakshman, M., Gopala Reddy, A., & Kalakumar, B. (2020). Study of Cadmium and Chlorpyrifos Induced Changes in Protein and Lipid Profile in Rats. Toxicology International, 27(1&amp;2), 54–57. https://doi.org/10.18311/ti/2020/v27i1&2/25279

Issue

Volume 27, Issue 1&2, January-June 2020

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-05-03
Accepted 2020-07-13
Published 2020-10-01

 

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