Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats

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Authors

  • Y. Ravikumar
     Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana ,IN
  • D. Madhuri
     Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Korutla, Jagtial District – 505326, Telangana ,IN
  • M. Lakshman
     Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana ,IN
  • A. Gopalareddy
     Controller of Examinations, PVNRTVU, Administrative Office, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana ,IN
  • B. Kalakumar
     Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Mamnoor, Warangal District – 506166 , Telangana ,IN
  • B. Anilkumar
     Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana ,IN

DOI:

https://doi.org/10.18311/ti/2022/v29i4/30251

Keywords:

Cadmium, Chlorpyrifos, Lipid Peroxidation, Wistar Rats.
VETERINARY PATHOLOGY

Abstract

The work was designed with 4 groups for 28 days. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Higher mean values of liver, kidney and brain TBARS were observed in G-2, 3 and 4 on 15th and 29th day. Liver section in group 2 revealed mild degenerative changes  in group 3; in group 4 mild to moderate peri portal fibrosis.  Kidney section in group 2 showed  shrunken glomeruli, necrosis;  kidney section showed degeneration and necrosis of tubular epithelium with casts in the lumen in group 3 and  necrosis with casts in the lumen in group 4. Brain section in group 2 showed mild perivascular cuffing,  mild to moderate degeneration of Purkinji cells in group 3 and in group 4 degeneration of Purkinje cells. Effects in G-4 were severe than individual groups due to synergistic action of the combined pollutants than the individual effects.

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Published

2023-02-07

How to Cite

Ravikumar, Y., Madhuri, D., Lakshman, M., Gopalareddy, A., Kalakumar, B., & Anilkumar, B. (2023). Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats. Toxicology International, 29(4), 475–480. https://doi.org/10.18311/ti/2022/v29i4/30251

Issue

Volume 29, Issue 4, December 2022

Section

Articles
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Scopus
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Europe PMC
Received 2022-05-12
Accepted 2022-06-16
Published 2023-02-07

 

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