Effect of Isolated Fraction from Biophytum reinwardtii on Dexamethasone Induced Insulin Resistance in Rats

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Authors

  • Nagaraju Bandaru
     College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Guntur - 522502, Andhra Pradesh ,IN
  • A. Narayana Rao
     College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Guntur - 522502, Andhra Pradesh ,IN
  • Yasho Deepika
     Department of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Hyderabad - 500088, Telangana ,IN
  • Alekhya Ketha
     Bharat Institute of Technology-Pharmacy, Mangalpally, Hyderabad - 501510, Telangana ,IN
  • Daveedu Thathipudi
     Department of Biotechnology, Vikarma Simhapuri University, Nellore – 524320, Andhra Pradesh ,IN
  • N. Sri Laxmi
     College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Guntur - 522502, Andhra Pradesh ,IN

DOI:

https://doi.org/10.18311/ti/2023/v30i1/26258

Keywords:

Antioxidants, Diabetes, Fraction, Insulin, Resistance
Pharmacology

Abstract

The Fraction from Methanolic extract whole plant of Biophytum reinwardtii (HEMBR) is traditionally used in the treatment of diabetes. Rats were treated with a standardized dose of Dexamethasone for 14 days and the effect of HEMBR at the doses of 50 and 100 mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD and catalase), and body weight were observed. HEMBR showed a significant decrease in plasma glucose and serum triglyceride levels (p < 0.01) at the dose of 50 and 100 mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes, GSH, SOD, and catalase were significantly increased (p < 0.01). Hence it can be concluded that Biophytum reinwardtii may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.

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Published

2023-03-20

How to Cite

Bandaru, N., Rao, A. N., Deepika, Y., Ketha, A., Thathipudi, D., & Sri Laxmi, N. (2023). Effect of Isolated Fraction from <i>Biophytum reinwardtii</i> on Dexamethasone Induced Insulin Resistance in Rats. Toxicology International, 30(1), 19–27. https://doi.org/10.18311/ti/2023/v30i1/26258

Issue

Volume 30, Issue 1, January-March 2023

Section

Articles
Crossref
Scopus
Google Scholar
Europe PMC
Received 2020-10-15
Accepted 2020-11-17
Published 2023-03-20

 

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