Herbs Used in Diabetic Wounds

Jump To References Section

Authors

  • Sunil Kardani
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara - 391760, Gujarat ,IN
  • Ghanshyam Parmar
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara - 391760, Gujarat ,IN
  • Rajesh Hadia
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara - 391760, Gujarat ,IN
  • Nirmal Shah
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara - 391760, Gujarat ,IN
  • Rahul Trivedi
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara - 391760, Gujarat ,IN
  • Sunil Baile
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara - 391760, Gujarat ,IN
  • Rajesh A. Maheshwari
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Vadodara - 391760, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2024/35424

Keywords:

Diabetes Management, Diabetic Wounds, Medicinal Herbs, Wound Healing

Abstract

Diabetic wounds present a formidable healthcare challenge due to their protracted healing process and heightened risk of complications. Fortunately, nature has bestowed us with a rich reserve of medicinal herbs steeped in centuries of traditional use, to foster wound healing and diabetes management. These herbs offer a promising avenue for addressing and overseeing diabetic wounds, providing potential advantages such as enhanced blood circulation, antimicrobial attributes and the mitigation of inflammation. In this article, we will explore the wide spectrum of herbs exhibiting potential in diabetic wound care. We will delve into their mechanisms of action, active constituents and the scientific substantiation endorsing their effectiveness in facilitating wound healing and addressing diabetic symptoms. Integrating these herbs into wound care regimens may expedite the healing process, diminish infection risks, relieve discomfort and conceivably elevate the overall well-being of those grappling with diabetes. Additionally, it is vital to consider individual variations in responses to these herbs, along with potential interactions with existing medications or allergies before incorporating them into a treatment regimen. Through our exploration of the captivating realm of herbs in diabetic wound care, we aspire to illuminate their therapeutic potential and contribute to the ongoing investigation and comprehension of natural remedies for diabetic wounds. Together, we can unveil the potency of nature in supporting the healing journey and enhancing the lives of individuals confronting the complexities of diabetes-related wound management.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2024-04-01

How to Cite

Kardani, S., Parmar, G., Hadia, R., Shah, N., Trivedi, R., Baile, S., & Maheshwari, R. A. (2024). Herbs Used in Diabetic Wounds. Journal of Natural Remedies, 24(4), 737–748. https://doi.org/10.18311/jnr/2024/35424

Issue

Volume 24, Issue 4, April 2024

Section

Short Review

License

Copyright (c) 2024 Sunil Kardani, Ghanshyam Parmar, Rajesh Hadia, Nirmal Shah, Rahul Trivedi, Sunil Baile, Rajesh A. Maheshwari (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Crossref
Scopus
Google Scholar
Europe PMC
Received 2023-10-25
Accepted 2024-02-12
Published 2024-04-01

 

References

Kumpatla S, Garg R. Current therapeutic options in diabetic foot ulcers. J Diabetes Complications. 2017; 31(4):716-23.

Panchawat S, Rathore HS. Herbal medicine: A potential adjunct in diabetic wound management. J Ayurveda Integr Med. 2017; 8(4): 244-49.

Gupta RK, Patel MB. Herbal wound healing preparations in India: Potential medicinal plants and formulations. Nat Prod Radiance. 2013; 12(4):293-307.

U.S. Food and Drug Administration. Dietary Supplements; 2021. Retrieved from: https://www.fda.gov/food/dietary-supplements

European Medicines Agency. 2017. Traditional herbal medicinal products. Retrieved from: https://www.ema.europa.eu/en/medicines/field_ema_web_categories%253Aname_field/Human/ema_group_types/ema_medicine

World Health Organization. 2004. Guidelines for the regulatory assessment of medicinal products for use in traditional medicine. Retrieved from: https://www.who.int/medicines/areas/traditional/TRMstatement.pdf

Hutter JA, Salmon M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, et al. Anti-inflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod. 1996; 59:541-3. https://doi.org/10.1021/np9601519 PMid:8778246.

Davis RH, Donato JJ, Hartman GM, Haas RC. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc. 1994; 84(2):77-81. https://doi.org/10.7547/87507315-84-2-77 PMid:8169808.

Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C. The efficacy of Aloe vera used for burn wound healing: A systematic review. Burns. 2007; 33(6):713-18. https://doi.org/10.1016/j.burns.2006.10.384. PMid:17499928.

Heggers J, Kucukcelebi A, Listengarten D, Stabenau J, Ko F, Broemeling LD, et al. Beneficial effect of aloe on wound healing in an excisional wound model. J Altern Complement Med. 1996; 2:271-7. https://doi.org/10.1089/acm.1996.2.271 PMid:9395659.

Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food. 2004; 7(1):61-6. https://doi.org/10.1089/109662004322984725 PMid:15117555.

Noor A, Gunasekaran S, Manickam AS, Vijayalakshmi MA. Antidiabetic activity of Aloe vera and histology of organs in streptozotocin induced diabetic rats. Curr Sci. 2008; 94(8):25.

Akinmoladun AC, Akinloye O. Prevention of the onset of hyperglycaemia by extracts of Aloe barbadensis in rabbits treated with alloxan. Afr J Biotechnol. 2007; 6(8):102.

Mohamed AE, Abdel-Aziz AF, El-Sherbiny EM, Mors RM. Anti-diabetic effect of Aloe vera juice and evaluation of thyroid function in female diabetic rats. Biosci Res. 2009; 6(1):28-34.

Preethi KC, Kuttan R. Wound healing activity of flower extract of Calendula officinalis. J Basic Clin Physiol Pharmacol. 2009; 20(1):73-9. https://doi.org/10.1515/JBCPP.2009.20.1.73 PMid:19601397.

Pommier P, Gomez F, Sunyach MP, D’Hombres A, Carrie C, Montbarbon X. Phase III randomised trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol. 2004; 22(8):1447-53. https://doi.org/10.1200/JCO.2004.07.063 PMid:15084618.

Kumar S, Kumar V, Prakash OM. Potential medicinal plants for wound healing an overview. Int J Pharm Sci Res. 2013; 4(2):455.

Prasad NR, Karthikeyan A, Karthikeyan S, Reddy BV. Inhibitory effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups. Curr Eye Res. 2004; 29(1):3-9.

Cherdshewasart W, Subtang S, Dahlan W. Major triterpenes of Centella asiatica stimulate collagen synthesis by human dermal fibroblasts in vitro. J Pharm Pharmacol. 2001; 53(5):721-28.

Shukla A, Rasik AM, Dhawan BN. Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother Res. 1999; 13(1):50-4. https://doi.org/10.1002/(SICI)1099-1573(199902)13:1<50::AID-PTR368>3.0.CO;2-V

Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol. 2006; 33(3):232-7. https://doi.org/10.1111/j.1440-1681.2006.04351.x PMid:16487267.

Gupta SS, Singh O, Bhagel PS, Moses S, Shukla S, Mathur RK. Honey dressing versus silver sulfadiazene dressing for wound healing in burn patients: A retrospective study. J Cutan Aesthet Surg. 2011; 4(3):183-7. https://doi.org/10.4103/0974-2077.91249 PMid:22279383 PMCid: PMC3263128.

Leach MJ, Kumar S. The clinical effectiveness of herbal medicine for the treatment of chronic wounds: A systematic review. Burns. 2014; 40(5):862-71.

Vlahović P, Arsenović M, Mitrović S, et al. Efficacy of Echinacea purpurea gel in the treatment of experimental skin wounds. Phytother Res. 2010; 24(2):276-82.

Korać RR, Khambholja KM. Potential of herbs in skin protection from ultraviolet radiation. Pharmacogn Rev. 2011; 5(10):164-73. https://doi.org/10.4103/0973-7847.91114 PMid:22279374 PMCid: PMC3263051.

Jadoon S, Karim S, Bin Asad MH, et al. Anti-inflammatory and analgesic activities of the extracts and compounds from the rhizomes of Cyperus rotundus Linn. J Ethnopharmacol.2012; 141(1):282-91.

Sharma V, Pandey D. Protective role of Rosmarinus officinalis against alloxan-induced diabetes in albino rats. J Ethnopharmacol. 2009; 122(1):91-4.

Gupta A, Malviya R. A prospective, randomised, double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012; 34(3):255-62. https://doi.org/10.4103/0253-7176.106022 PMid:23439798 PMCid: PMC3573577.

Wang JR, Zhou F, Li Y, Wang F, Wang X, Yuan QJ. Rehmanniae radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology. J Ethnopharmacol. 2017; 198:351-62. https://doi.org/10.1016/j.jep.2017.01.021 PMid:28111216.

Xu R, Hu J, Zhang Z, et al. Radix Rehmanniae extract promotes cutaneous wound healing by activating angiogenesis via upregulation of eNOS, MMP-9 and VEGF. Br J Pharmacol. 2017; 174(9):1427-48.

Kumaravel S, Vinothkumar V, Mohan A, et al. Wound healing activity of Annona squamosa extract in diabetic rats. J Ethnopharmacol. 2012; 144(1):203-09.

Prasad SB, Kanakasabapathy I, Ramachandran S, et al. Wound-healing potential of Annona squamosa seed extract. Pharm Biol. 2014; 52(2):196-204.

Amin FU, Shah SA, Kim MO. Pomegranate extract inhibits the expression of genes involved in skin inflammation and tissue remodeling in UVB-irradiated mice-Evid Based Complement Alternat Med. 2013; 2013:410705.

Siddiqui IA, Adhami VM, Bharali DJ, et al. Introducing copper into a pomegranate-derived tannin inhibits prostate carcinoma growth and enhances chemosensitivity. Carcinogenesis. 2011; 32(6):856-64.

Alzahrani HA, Alsarra IA, Alsarra IA, et al. Acceleration of wound healing potential by topical application of Echinacea purpurea Linn on diabetic rats. Phytomedicine. 2012; 19(10):896-902.

Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015; 2015(3):CD005083. https://doi.org/10.1002/14651858.CD005083.pub4. PMid:25742878 PMCid: PMC9719456.

Radix SM, Abdollahi M, Khorram Khorshid HR, Hassanzadeh G, Soltani A, Abnous K. The healing effect of topical Comfrey on symptomatic distal radius fracture: A randomised, double-blind, placebo-controlled clinical trial. Iran Red Crescent Med J. 2016; 18(4):e23634.

Windrum P, Sumbayev VV. Wound healing activity of Symphytum × Uplandicum nyman (common comfrey) extracts. Phytother Res. 2011; 25(9):1376-83.

Peana AT, D’Aquila PS, Panin F, Serra G, Pippia P, Moretti MDL. Anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils. Phytomedicine. 2002; 9(8):721-26. https://doi.org/10.1078/094471102321621322 PMid:12587692.

Okmen G, Turkkan E, Yuceer M, et al. Anti-inflammatory and wound healing effects of lavender oil in a rat model of excision wound. Anatol J Clin Investig. 2018; 12(3):240-5.

Abdel-Tawab HM, Khalifa AE, Abdel-Aziz H, et al. Allium sativum and Allium cepa oils exhibit considerable antimicrobial activities and control the growth of pathogenic microorganisms. Microb Pathog. 2017; 107:1-7.

Keshari AK, Srivastava R, Singh P, et al. Topical application of Allium sativum and Crocus sativus extracts on excision wound healing in rabbits. Curr Tradit Med. 2020; 6(2):182-8.

Surjushe A, Vasani R, Saple DG. Aloe vera: A short review. Indian J Dermatol. 2008; 53(4):163-6. https://doi.org/10.4103/0019-5154.44785 PMid:19882025 PMCid: PMC2763764.

Preethi KC, Kuttan R. Wound healing activity of flower extract of Calendula officinalis. J Basic Clin Physiol Pharmacol. 2009; 20(1):73-9. https://doi.org/10.1515/JBCPP.2009.20.1.73 PMid:19601397.

Hewlings SJ, Kalman DS. Curcumin: A review of its effects on human health. Foods. 2017; 6(10):92. https://doi.org/10.3390/foods6100092 PMid:29065496 PMCid:PMC5664031.

Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica. Phytomedicine. 2000; 7(5):427-48. https://doi.org/10.1016/S0944-7113(00)80065-3 PMid:11081995.

Evans WC. Trease and Evans’ Pharmacognosy. 16th ed. Elsevier; 2009.

Most read articles by the same author(s)

1 2 > >>