Immunomodulating Effects of Allium sativum in Renal Tissue of LPS Challenged Mice
Authors
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Department of Bioscience and Biotechnology, Banasthali Vidyapith, Vanasthali Road - 304022, Rajasthan ,IN
Kanchan Sharma -
Department of Bioscience and Biotechnology, Banasthali Vidyapith, Vanasthali Road - 304022, Rajasthan ,INVeena Sharma
DOI:
https://doi.org/10.18311/ti/2019/v26i3&4/24111Keywords:
Allium sativum, Anti-inflammatory, Cytokines, Lipopolysaccharide (LPS), NF-kBAbstract
Allium sativum contain various medicinal properties like immunomodulatory, antitumorigenetic, antiatherosclerotic and antimicrobial. In the present study, we analyzed the impact of hydroethanol extract of Allium sativum on cytokine production in LPS challenged mice. LPS significantly induced the activation of NF-kB and also increased the levels of NO, TNF-α, IL-6, IFN-Y, PGE2 with the suppression of IL-10 production. In the results we found that Allium sativum significantly attenuated the LPS-induced phosphorylation of NF-ĸB and normalized the levels of NO, TNF-α, IL-6, IFN-Y, PGE-2 and IL-10. In summary, it was deduced that garlic may promote an anti-inflammatory effect by inhibition of NF-kB activity in the tissue.
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Accepted 2020-01-21
Published 2020-07-20
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